Description

(5'S)-8,5'-Cyclodeoxyadenosine Ce Phosphoramidite is a specialized, high-purity phosphoramidite monomer used in the solid-phase synthesis of oligonucleotides. This compound is critical for introducing site-specific modifications into DNA strands, enabling advanced research in molecular biology and therapeutic development. It is an essential building block for pharmaceutical R&D, diagnostic assay development, and academic research focused on nucleic acid chemistry and antisense technologies.

Application

• Oligonucleotide Synthesis: Key monomer for the automated solid-phase synthesis of modified DNA strands.
• Antisense & siRNA Therapeutics: Used to create research-grade and therapeutic oligonucleotides with enhanced stability or targeting properties.
• Diagnostic Probe Development: Manufacture of labeled probes for PCR, sequencing, and microarray applications requiring specific base modifications.
• Structural Biology Studies: Synthesis of oligonucleotides containing cyclonucleoside lesions for studying DNA damage and repair mechanisms.
• Apitamer Discovery: Building block in SELEX libraries to generate modified aptamers with improved binding affinity and nuclease resistance.
• Basic Research: Tool for investigating the structure-function relationships of nucleic acids and their interactions with proteins.

Basic Information

Product Name	(5'S)-8,5'-Cyclodeoxyadenosine Ce Phosphoramidite
CAS No.	211919-91-4
Molecular Formula	C31H39N6O5P
Molecular Weight	606.66 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-(5'S)-8,5'-cyclo-2'-deoxyadenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 8,5'-cyclo-dA-CE Phosphoramidite; (5'S)-c8,5'-cyclo-dA Phosphoramidite; 5'-DMT-8,5'-cyclo-2'-deoxyadenosine-3'-CE Phosphoramidite; N6-Bz-(5'S)-8,5'-cyclo-dA-CE Phosphoramidite; Cyclodeoxyadenosine Phosphoramidite
EINECS	Contact for details

Quality Control

Our (5'S)-8,5'-Cyclodeoxyadenosine Ce Phosphoramidite is manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive oligonucleotide synthesis. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content. We adhere to GMP principles for production and quality management to support our customers in research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.