Description

Bicyclo[3.2.1]Oct-6-En-3-One, 2,4-Difluoro-, (1R,2S,4R,5S)-Rel- (9Ci) is a high-purity, stereochemically defined fluorinated bicyclic ketone, serving as a sophisticated chiral building block for advanced organic synthesis. Its unique rigid structure and fluorine substitution pattern make it a critical intermediate for developing novel compounds with tailored biological and physical properties. This product is essential for research and development chemists in the pharmaceutical and agrochemical industries, where precise molecular architecture is paramount for creating next-generation active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of novel herbicides and pesticides, where the fluorine atoms and bicyclic scaffold can enhance bioavailability and environmental stability.
• Material Science Precursor: Serves as a building block for specialty polymers and advanced materials requiring specific fluorinated, rigid molecular components.
• Asymmetric Catalysis Ligand Synthesis: The defined stereocenters make it a valuable starting material for constructing chiral ligands and organocatalysts.
• Academic & Contract Research: A valuable tool for methodological development in organic synthesis and fluorine chemistry within university and CRO laboratories.

Basic Information

Product Name	Bicyclo[3.2.1]Oct-6-En-3-One, 2,4-Difluoro-, (1R,2S,4R,5S)-Rel- (9Ci)
CAS No.	211568-30-8
Molecular Formula	C8H8F2O
Molecular Weight	158.15 g/mol
Synonyms	(1R,2S,4R,5S)-2,4-Difluorobicyclo[3.2.1]oct-6-en-3-one; rel-(1R,2S,4R,5S)-2,4-Difluorobicyclo[3.2.1]oct-6-en-3-one; 2,4-Difluorobicyclo[3.2.1]oct-6-en-3-one, (1R,2S,4R,5S)-rel-; Bicyclo[3.2.1]oct-6-en-3-one, 2,4-difluoro-, (1R,2S,4R,5S)-rel-; 211568-30-8; 2,4-Difluoro-3-bicyclo[3.2.1]oct-6-enone (stereospecific)
EINECS	Contact for details

Quality Control

Every batch of our fluorinated chiral intermediates is produced under strict quality management protocols. We employ advanced analytical techniques including chiral HPLC, GC, NMR (¹H, ¹⁹F, ¹³C), and mass spectrometry to ensure exacting standards for identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all relevant specifications is provided with each shipment, ensuring full traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.