Description

3′-o-Allyl Dt is a specialized nucleoside derivative, a crucial building block in oligonucleotide synthesis and medicinal chemistry research. Its primary value lies in enabling the precise chemical modification of nucleic acids, which is essential for developing advanced therapeutics and diagnostic tools. This high-purity intermediate is particularly vital for pharmaceutical R&D teams and fine chemical manufacturers focused on antisense oligonucleotides, siRNA, and other cutting-edge genetic medicines.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA/RNA strands.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides (ASOs) for targeted gene silencing therapies.
• siRNA and miRNA Research: Enables the introduction of specific modifications to enhance the stability, delivery, and efficacy of RNA interference (RNAi) agents.
• Medicinal Chemistry: Serves as a versatile scaffold for exploring structure-activity relationships (SAR) in nucleoside-based drug candidates.
• Diagnostic Probe Development: Incorporated into labeled probes for genetic testing, fluorescence in situ hybridization (FISH), and other molecular diagnostics.
• Bioconjugation: The allyl group provides a handle for further functionalization and conjugation with reporter molecules or delivery vehicles.

Basic Information

Product Name	3′-o-Allyl Dt
CAS No.	211191-57-0
Molecular Formula	C13H17N2O5
Molecular Weight	281.29 g/mol
Synonyms	3′-O-Allylthymidine; 1-((2R,4S,5R)-4-Allyloxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; 3′-O-Allyl-2′-deoxythymidine; Allyl Thymidine Derivative; 3′-Allyloxy Thymidine; 5-Methyl-2′-deoxyuridine 3′-(2-propenyl) ether; DT Allyl Ether
EINECS	Contact for details

Quality Control

Every batch of 3′-o-Allyl Dt is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.