Description

N4-Benzoyl-2'-o-Propargyladenosine is a chemically modified nucleoside derivative, specifically engineered for advanced research and pharmaceutical development. This compound serves as a critical synthetic intermediate and a versatile building block in the creation of novel therapeutic agents and biochemical probes. It is primarily utilized by researchers and manufacturers in the fields of nucleoside chemistry, medicinal chemistry, and oligonucleotide synthesis, where precise molecular modifications are essential for drug discovery and diagnostic applications.

Application

• Medicinal Chemistry Research: A key intermediate in the synthesis of novel adenosine receptor ligands and other nucleoside-based pharmaceuticals.
• Oligonucleotide Synthesis: Used as a modified phosphoramidite precursor for incorporating propargyl-functionalized adenosine into DNA/RNA strands for click chemistry applications.
• Bioconjugation & Probe Development: The propargyl group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling and attaching biomolecules.
• Antiviral & Anticancer Agent Development: Investigated as a building block for creating nucleoside analogs with potential therapeutic activity.
• Biochemical Tool Compound: Employed in enzymatic studies to investigate the substrate specificity of kinases and other nucleoside-processing enzymes.
• Academic & Industrial R&D: Serves as a specialized reagent for exploratory synthesis in university and corporate research laboratories.

Basic Information

Product Name	N4-Benzoyl-2'-o-Propargyladenosine
CAS No.	210096-44-9
Molecular Formula	C21H20N6O5
Molecular Weight	436.42 g/mol
Synonyms	2'-O-Propargyl-N6-benzoyladenosine; N6-Benzoyl-2'-O-propargyladenosine; 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-(prop-2-yn-1-yloxy)oxolan-2-yl]-N-(phenylcarbonyl)purin-6-amine; 2'-O-Propargyl-N6-Bz-Ado; Bz-2'-O-propargyl-adenosine; Adenosine, N6-benzoyl-2'-O-(2-propynyl)-
EINECS	Contact for details

Quality Control

Our N4-Benzoyl-2'-o-Propargyladenosine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.