Description

N6-Benzoyl-2'-O,4'-C-Methyleneadenosine is a chemically modified nucleoside derivative, specifically a bridged nucleic acid (BNA) analog. This compound is of significant value in the field of oligonucleotide synthesis and medicinal chemistry, where it serves as a crucial building block for creating nuclease-resistant antisense and siRNA therapeutics. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing advanced nucleic acid-based drugs and diagnostic probes.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A key phosphoramidite monomer for constructing oligonucleotides with enhanced binding affinity and stability.
• siRNA and miRNA Therapeutics: Used to introduce chemical modifications that improve pharmacokinetic properties and reduce off-target effects in RNA interference applications.
• Diagnostic Probe Development: Employed in the creation of high-specificity probes for fluorescence in situ hybridization (FISH) and other molecular diagnostic assays.
• Medicinal Chemistry Research: Serves as a critical intermediate in the discovery and optimization of novel nucleoside-based drug candidates.
• Bioconjugation and Labeling: The benzoyl protecting group and unique structure allow for specific conjugation strategies in biophysical studies.
• Academic & Industrial R&D: A vital reagent for studying nucleic acid structure, function, and for developing novel bio-active compounds.

Basic Information

Product Name	N6-Benzoyl-2'-O,4'-C-Methyleneadenosine
CAS No.	209968-94-5
Molecular Formula	C18H17N5O5
Molecular Weight	383.36 g/mol
Synonyms	2'-O,4'-C-Methyleneadenosine N6-benzoyl derivative; Bn-A(Bz); 6-Benzamido-9-[(1R,3R,4R,7S)-7-hydroxy-2,5-dioxa-8-oxabicyclo[2.2.1]hept-1-yl]-9H-purine; N6-Benzoyl-2',4'-BNA-A; 2'-O,4'-C-Methylene adenosine 6-N-benzoyl; LNA-A(Bz); Bridged Nucleic Acid Adenosine (N6-Benzoyl); N-Bz-2'-O,4'-C-methyleneadenosine
EINECS	Contact for details

Quality Control

Our N6-Benzoyl-2'-O,4'-C-Methyleneadenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.