Description

Ms-275 Hydrochloride is a high-purity, small molecule compound of significant interest in pharmaceutical research and development. This compound serves as a potent and selective inhibitor of histone deacetylase (HDAC) enzymes, a key mechanism being explored for therapeutic applications. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology, neurology, and epigenetics research to study disease pathways and develop novel treatments.

Application

• Pharmaceutical R&D: Used as a reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel HDAC inhibitor therapies.
• Oncology Research: Investigated in preclinical studies for its potential anti-cancer properties against various tumor cell lines.
• Biochemical Assays: Employed as a critical tool compound in enzymatic assays to study HDAC activity and inhibition kinetics.
• Epigenetics Studies: Utilized in cellular and molecular biology research to modulate gene expression by altering histone acetylation status.
• Neurological Disease Models: Applied in research models for neurodegenerative diseases where epigenetic regulation is a target.

Basic Information

Product Name	Ms-275 Hydrochloride
CAS No.	209784-80-5
Molecular Formula	C₂₁H₂₀N₄O₃ • HCl
Molecular Weight	424.87 g/mol (free base: 376.41 g/mol)
Synonyms	Entinostat Hydrochloride; SNDX-275; MS-275; N-(2-Aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide hydrochloride; HDAC inhibitor MS-275; Benzamide, N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]-, monohydrochloride
EINECS	Contact for details

Quality Control

Our Ms-275 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm
Assay (on dried basis)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.