Description

Entinostat is a potent and selective Class I histone deacetylase (HDAC) inhibitor, specifically targeting HDAC1, HDAC2, and HDAC3. This compound is a critical research tool and pharmaceutical intermediate for developing novel epigenetic therapies in oncology. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and CROs focused on cancer biology and drug discovery. The product is supplied as a high-purity reference standard and building block for advanced synthesis.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel cancer therapeutics.
• Epigenetics & Cancer Biology Studies: Used in vitro and in vivo to investigate the role of HDAC inhibition in gene expression, cell cycle arrest, and apoptosis.
• Preclinical Drug Candidate: Serves as a lead compound for structural optimization and the synthesis of new HDAC inhibitor analogs.
• Biochemical Assay Development: Employed as a control inhibitor in high-throughput screening (HTS) assays to identify and validate new epigenetic targets.
• Academic Research: A vital reagent for studying chromatin remodeling, transcriptional regulation, and their implications in various disease models beyond oncology.

Basic Information

Product Name	Entinostat
CAS No.	209783-80-2
Molecular Formula	C21H20N4O2
Molecular Weight	360.41 g/mol
Synonyms	MS-275; SNDX-275; N-(2-Aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide; Benzamide, N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]-; HDAC inhibitor MS-275; Entinostatum
EINECS	Contact for details

Quality Control

Our Entinostat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reliable and reproducible results for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.