Description

4-Phenyl-5-(Trifluoromethyl)-2-Thiophenecarbonyl Chloride is a high-value, multi-functional chemical building block characterized by its reactive acid chloride group and trifluoromethyl-substituted thiophene core. This compound matters for its critical role in the synthesis of complex organic molecules, particularly in advanced pharmaceutical and agrochemical research where the introduction of fluorine atoms and heterocyclic systems is essential for modulating biological activity and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Active Ingredient Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: An essential reagent in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Fluorinated Compound Library Synthesis: Employed in combinatorial chemistry and high-throughput screening to create diverse libraries of fluorinated compounds for biological evaluation.

Basic Information

Product Name	4-Phenyl-5-(Trifluoromethyl)-2-Thiophenecarbonyl Chloride
CAS No.	208108-75-2
Molecular Formula	C12H6ClF3OS
Molecular Weight	290.69 g/mol
Synonyms	2-Thiophenecarbonyl chloride, 4-phenyl-5-(trifluoromethyl)-; 5-(Trifluoromethyl)-4-phenyl-2-thiophenecarbonyl chloride; 4-Phenyl-5-(trifluoromethyl)thiophene-2-carbonyl chloride; 2-Thenoyl chloride, 4-phenyl-5-(trifluoromethyl)-; 208108-75-2; 4-Phenyl-5-trifluoromethylthiophene-2-carbonyl chloride
EINECS	Contact for details

Quality Control

Our 4-Phenyl-5-(Trifluoromethyl)-2-Thiophenecarbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.