Description

2-Fluoro-5-(Trifluoromethyl)Benzoyl Chloride is a high-value fluorinated aromatic acid chloride derivative. This compound serves as a critical building block in advanced organic synthesis, enabling the introduction of a functionalized benzoyl group. It is primarily utilized by R&D and production chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl and fluorine substituents enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorinated components in electronic display materials, improving dielectric anisotropy and stability.
• Polymer Modification: Employed to introduce fluorinated benzoyl groups into polymer chains, altering surface properties, chemical resistance, and thermal stability.
• Organic Synthesis Reagent: A versatile reagent for Friedel-Crafts acylation, amide coupling, and esterification reactions in complex molecule construction.
• Dye & Pigment Manufacturing: Intermediate for creating specialized fluorinated dyes and pigments with unique color fastness and spectral properties.

Basic Information

Product Name	2-Fluoro-5-(Trifluoromethyl)Benzoyl Chloride
CAS No.	207981-46-2
Molecular Formula	C8H3ClF4O
Molecular Weight	226.56 g/mol
Synonyms	2-Fluoro-α,α,α-trifluoro-m-toluoyl chloride; 2-Fluoro-5-(trifluoromethyl)benzoic acid chloride; 5-(Trifluoromethyl)-2-fluorobenzoic acid chloride; 2-Fluor-5-(trifluormethyl)benzoylchlorid; m-Trifluoromethyl-o-fluorobenzoic acid chloride; 2-Fluoro-α,α,α-trifluoro-m-toluic acid chloride; Benzoyl chloride, 2-fluoro-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-(Trifluoromethyl)Benzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.