Description

2-Thiophenecarbonyl Chloride, 5-Fluoro- (9Ci) is a high-value fluorinated heterocyclic building block essential for advanced organic synthesis. This compound is a critical reagent for introducing the 5-fluoro-2-thiophenecarbonyl moiety into target molecules, enabling the development of novel materials and active ingredients. It is primarily sought by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating new compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atom and thiophene ring can improve bioactivity and environmental stability.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, and organic electronic materials requiring specific fluorinated thiophene units.
• Chemical Biology & Proteomics: Employed as a reactive handle for labeling and modifying biomolecules in probe development and bioconjugation strategies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up campaigns in fine chemical production.

Basic Information

Product Name	2-Thiophenecarbonyl Chloride, 5-Fluoro- (9Ci)
CAS No.	207849-74-9
Molecular Formula	C5H2ClFOS
Molecular Weight	164.58 g/mol
Synonyms	5-Fluoro-2-thiophenecarbonyl chloride; 5-Fluorothiophene-2-carbonyl chloride; 5-Fluoro-2-thenoyl chloride; 5-Fluorothiophene-2-carboxylic acid chloride; 2-Thenoyl chloride, 5-fluoro-; 5-Fluoro-2-thienoyl chloride; 5-Fluorothiophene-2-carbonyl chloride (9CI); 5-Fluoro-2-thiophenecarboxylic acid chloride
EINECS	Contact for details

Quality Control

Our production of 2-Thiophenecarbonyl Chloride, 5-Fluoro- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP manufacturing requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Clear to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.