Description

2-(4-Chlorophenyl)-2,2-Difluoroethanol is a versatile fluorinated aromatic alcohol building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of pharmaceuticals and agrochemicals, where the difluoroethanol moiety can impart desirable metabolic stability and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic side chains to modulate potency and pharmacokinetics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies.
• Polymer Science: Employed as a monomer or modifier in the synthesis of specialty polymers with unique surface properties and chemical resistance.
• Organic Synthesis Reagent: Utilized in various organic transformations, including nucleophilic substitutions and esterifications, to introduce the 2,2-difluoroethanol functional group.
• Material Science Research: Acts as a starting material for creating novel fluorinated materials with specific dielectric or surface energy characteristics.

Basic Information

Product Name	2-(4-Chlorophenyl)-2,2-Difluoroethanol
CAS No.	207799-86-8
Molecular Formula	C8H7ClF2O
Molecular Weight	192.59 g/mol
Synonyms	2,2-Difluoro-2-(4-chlorophenyl)ethanol; 4-Chloro-α,α-difluorobenzeneethanol; 1-(4-Chlorophenyl)-2,2-difluoroethan-1-ol; (4-Chlorophenyl)difluoromethyl carbinol; α,α-Difluoro-4-chlorobenzeneethanol; 2-(p-Chlorophenyl)-2,2-difluoroethanol; p-Chloro-α,α-difluorobenzyl alcohol
EINECS	Contact for details

Quality Control

Our 2-(4-Chlorophenyl)-2,2-Difluoroethanol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.