Description

Rilmenidine Hemifumarate Salt CAS NO 207572-68-7 is the hemifumarate salt form of Rilmenidine, a highly selective I1-imidazoline receptor agonist. This compound is a key pharmaceutical intermediate and reference standard in cardiovascular research and drug development. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in the synthesis of antihypertensive agents and neuropharmacological studies.

Application

• Pharmaceutical Active Ingredient (API) Synthesis: Serves as a critical intermediate in the manufacturing of Rilmenidine-based antihypertensive medications.
• Reference Standard for QC/QA: Used as a high-purity standard in analytical laboratories for method development, validation, and quality control testing of drug substances and products.
• Preclinical & Clinical Research: Employed in pharmacological studies to investigate central mechanisms of blood pressure regulation and I1-receptor activity.
• Formulation Development: Used in R&D for developing various dosage forms, ensuring stability and efficacy of the final drug product.
• Metabolite Studies: Acts as a starting material or standard for the synthesis and identification of drug metabolites in ADME (Absorption, Distribution, Metabolism, and Excretion) research.

Basic Information

Product Name	Rilmenidine Hemifumarate Salt
CAS No.	207572-68-7
Molecular Formula	C10H17N3O • 0.5C4H4O4
Molecular Weight	266.30 g/mol (for the hemifumarate salt)
Synonyms	Rilmenidine Fumarate (1:0.5); Rilmenidine Hydrogen Fumarate; (R,S)-2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-4,5-dihydro-6-methyl-1,3-oxathiane Hemifumarate; S 3341; S-3341; S3341; Oxaminozoline Hemifumarate; Tenaxum
EINECS	Contact for details

Quality Control

Our Rilmenidine Hemifumarate Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profiling by HPLC, to ensure it meets high-purity standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every lot.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.