Description

2'-o-Propygylguanosine is a chemically modified nucleoside derivative, specifically a guanosine analog with a propargyl ether group at the 2'-hydroxyl position. This modification is critical for its primary role as a key building block in oligonucleotide synthesis, enabling advanced applications in molecular biology and therapeutic development. It is essential for researchers and manufacturers in the fields of pharmaceutical R&D, diagnostic probe development, and antisense oligonucleotide (ASO) production.

Application

• Oligonucleotide Synthesis: A crucial phosphoramidite precursor for solid-phase synthesis of modified RNA and DNA strands.
• Click Chemistry Conjugation: The propargyl group enables efficient, site-specific bioconjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling probes.
• Therapeutic Nucleic Acid Development: Used in the research and production of antisense oligonucleotides (ASOs), siRNA, and aptamers with enhanced stability.
• Diagnostic Probe Manufacturing: Incorporated into fluorescent or affinity-tagged probes for in situ hybridization and detection assays.
• Biochemical Research: Serves as a tool compound for studying RNA structure, function, and protein-RNA interactions.
• Academic & Industrial R&D: Fundamental material for exploring novel nucleic acid-based technologies and drug candidates.

Basic Information

Product Name	2'-o-Propygylguanosine
CAS No.	206552-86-5
Molecular Formula	C13H15N5O5
Molecular Weight	321.29 g/mol
Synonyms	2'-O-Propargylguanosine; 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-(prop-2-yn-1-yloxy)oxolan-2-yl]-1,9-dihydro-6H-purin-6-one; Guanosine, 2'-O-(2-propynyl)-; 2'-O-Propygyl-Guanosine; 2'-Propargyl Guanosine; 2'-O-(Prop-2-yn-1-yl)guanosine
EINECS	Contact for details

Quality Control

Our 2'-o-Propygylguanosine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for sensitive research and production applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.