Description

Rac Lafutidine CAS NO 206449-93-6 is a racemic mixture of the histamine H₂-receptor antagonist Lafutidine. This compound is of significant interest in pharmaceutical research and development, particularly for studying the stereoselective pharmacology and metabolism of the active enantiomer. It serves as a critical intermediate and reference standard for analytical and synthetic purposes. Key industries that utilize this material include pharmaceutical R&D, contract manufacturing organizations (CMOs), and academic research institutions focused on gastroenterology and receptor pharmacology.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control and analytical method development in drug manufacturing.
• Active Pharmaceutical Ingredient (API) Research: Serves as a starting material or intermediate in the research and synthesis of novel H₂-receptor antagonists.
• Metabolic and Pharmacokinetic Studies: Employed in preclinical studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of lafutidine enantiomers.
• Analytical Chemistry: Used to develop and validate chromatographic methods (e.g., HPLC, LC-MS) for enantiomeric separation and purity analysis.
• Academic and Institutional Research: A key reagent for fundamental studies in medicinal chemistry and pharmacology related to gastroprotective agents.

Basic Information

Product Name	Rac Lafutidine
CAS No.	206449-93-6
Molecular Formula	C₂₂H₂₉N₃O₄S
Molecular Weight	431.55 g/mol
Synonyms	Lafutidine Racemate; (±)-Lafutidine; 2-[(2-Furanylmethyl)sulfinyl]-N-[[4-[[4-(piperidin-1-ylmethyl)pyridin-2-yl]oxy]but-2E-enyl]acetamide; FRG-8813 (racemate); Protecadin (racemate); ULG-LF-01
EINECS	Contact for details

Quality Control

Our Rac Lafutidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing results from tests such as HPLC assay, chiral purity, residual solvents, and related substances. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	Racemic mixture (50:50 ratio of enantiomers)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.