Description

Benzamide, n-[9-[2,5-Anhydro-4-C-[[Bis(4-Methoxyphenyl)Phenylmethoxy]Methyl]-α-L-Lyxofuranosyl]-9H-Purin-6-Yl]- is a specialized nucleoside analog building block of significant interest in advanced pharmaceutical research and development. This high-purity intermediate is critical for the synthesis of modified oligonucleotides and nucleotide-based therapeutics. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antisense drugs, siRNA, and other novel therapeutic modalities targeting genetic expression. The compound, identified by CAS No. 206055-74-5, offers a precise chemical handle for constructing complex biomolecules with specific activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop nucleotide analogs with enhanced stability, binding affinity, and pharmacokinetic properties.
• Prodrug Development: Serves as a precursor in the design of nucleotide prodrugs aimed at improving cellular uptake and bioavailability.
• Bioconjugation: The reactive benzamide group allows for site-specific conjugation to targeting ligands, dyes, or other functional molecules in diagnostic probe development.
• Academic & Institutional R&D: Fundamental research tool for studying nucleic acid chemistry, enzyme mechanisms, and gene function.
• Process Development & Scale-up: Sourced by CDMOs (Contract Development and Manufacturing Organizations) for pilot-scale and commercial manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Benzamide, n-[9-[2,5-Anhydro-4-C-[[Bis(4-Methoxyphenyl)Phenylmethoxy]Methyl]-α-L-Lyxofuranosyl]-9H-Purin-6-Yl]-
CAS No.	206055-74-5
Molecular Formula	C43H39N5O8
Molecular Weight	753.80 g/mol
Synonyms	N-[9-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-α-L-lyxofuranosyl]-9H-purin-6-yl]benzamide; 6-N-Benzoyl-2',3'-dideoxy-2',3'-seco-5'-O-(4,4'-dimethoxytrityl)adenosine; 5'-O-DMT-2',3'-seco-2',3'-dideoxy-6-N-benzoyladenosine; DMT-2',3'-Seco-ddA(Bz) Amidite Precursor; 2',3'-Seco Nucleoside Intermediate; Benzoylated Seco-nucleoside; Anhydrolyxofuranosyl Purine Benzamide Derivative
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and traceability. Each lot undergoes comprehensive analytical characterization using techniques such as HPLC, NMR, and mass spectrometry to confirm identity, purity, and absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting specifications for assay, related substances, residual solvents, and water content. We support compliance with cGMP (Current Good Manufacturing Practice) guidelines for drug substance intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccant use and storage under an inert atmosphere (e.g., argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.