Description

N2-Isobutyryl-2'-O,4'-C-Methyleneguanosine is a chemically modified nucleoside derivative, specifically engineered for advanced oligonucleotide synthesis. This compound is a critical building block in the production of antisense oligonucleotides and small interfering RNAs (siRNAs), where it enhances stability and target affinity. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing next-generation therapeutic nucleic acids.

Application

• Therapeutic Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of antisense drugs and siRNA therapeutics.
• RNA Research & Development: Used in the study of RNA structure, function, and metabolism, particularly for introducing nuclease-resistant modifications.
• Diagnostic Probe Development: Serves as a modified base in the construction of high-affinity, stable nucleic acid probes for diagnostic assays.
• Pharmaceutical Intermediates: An important intermediate in the cGMP-compliant manufacturing process of active pharmaceutical ingredients (APIs) for nucleic acid-based therapies.
• Bioconjugation & Labeling: Provides a reactive handle for further chemical modifications and conjugation with reporter molecules or delivery vehicles.

Basic Information

Product Name	N2-Isobutyryl-2'-O,4'-C-Methyleneguanosine
CAS No.	206055-68-7
Molecular Formula	C16H21N5O6
Molecular Weight	379.37 g/mol
Synonyms	2'-O,4'-C-Methylene-N2-isobutyrylguanosine; 2'-O,4'-C-Methylene-N2-isobutyryl-guanosine; N2-Isobutyryl-2'-O,4'-C-methyleneguanosine; Bn-G(m) Phosphoramidite precursor; LNA-G(Ibu) monomer; 9-[(2R,3R,4R,5R)-5-[[(2R,3S)-3,4-Dihydro-5-methyl-2,3-furandiy]bis(oxy)]-3,4-dihydroxyoxolan-2-yl]-2-(2-methylpropanoylamino)-1H-purin-6-one
EINECS	Contact for details

Quality Control

Our N2-Isobutyryl-2'-O,4'-C-Methyleneguanosine is manufactured under strict quality systems suitable for research and pharmaceutical intermediate applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure consistency and reliability. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.