Description

1H-Indole-3-Carbonyl Chloride, 1-Methoxy- (9Ci) is a specialized, high-purity chemical building block used in advanced organic synthesis. This compound is critical for the efficient introduction of the 1-methoxyindole-3-carbonyl moiety into target molecules, enabling the development of novel compounds with specific functionalities. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and complex intermediates. Its precise reactivity makes it a valuable reagent for medicinal chemistry and material science applications.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the indole scaffold is a common structural motif.
• Material Science Research: Employed in the creation of organic semiconductors, dyes, and photoactive materials due to its conjugated indole system.
• Peptide Mimetics: Serves as a precursor for unnatural amino acids or peptide side-chain modifications in biochemical research.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Academic and Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting exploratory synthetic chemistry.

Basic Information

Product Name	1H-Indole-3-Carbonyl Chloride, 1-Methoxy- (9Ci)
CAS No.	205253-72-1
Molecular Formula	C10H8ClNO2
Molecular Weight	209.63 g/mol
Synonyms	1-Methoxyindole-3-carbonyl chloride; 1-Methoxy-1H-indole-3-carbonyl chloride; 1-Methoxy-1H-indole-3-carboxylic acid chloride; 1-Methoxyindole-3-carboxylic acid chloride; 1-Methoxy-3-(chlorocarbonyl)indole; 3-Carboxy-1-methoxyindole chloride; 1-Methoxy-1H-indole-3-carboxychloride
EINECS	Contact for details

Quality Control

Our 1H-Indole-3-Carbonyl Chloride, 1-Methoxy- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically exceeding 97% (HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical and advanced research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Solubility	Soluble in common organic solvents (e.g., DCM, THF, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.