Description

1-Pyrrolidinecarbonyl Chloride, 2-(Methoxymethyl)-, (2S)- (9Ci) is a chiral, highly reactive acyl chloride derivative used as a key building block in advanced organic synthesis. Its value lies in its ability to introduce a specific, functionalized pyrrolidine moiety, which is a privileged scaffold in medicinal chemistry. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for creating stereochemically defined molecules. The product is supplied with a guaranteed Certificate of Analysis to ensure batch-to-batch consistency and reliability for your critical synthetic pathways.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting the central nervous system (CNS) and other therapeutic areas.
• Agrochemical Research: Used in the development of novel, stereoselective pesticides and herbicides where the specific spatial orientation of the molecule is crucial for bioactivity.
• Peptidomimetics & PROTACs: Serves as a building block for constructing complex peptidomimetic structures and Proteolysis-Targeting Chimeras (PROTACs) in drug discovery.
• Ligand & Catalyst Development: Employed in the preparation of specialized chiral ligands and organocatalysts for asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.
• Academic & R&D Laboratories: Used in university and institutional research for methodological development and exploring new chemical spaces in organic chemistry.

Basic Information

Product Name	1-Pyrrolidinecarbonyl Chloride, 2-(Methoxymethyl)-, (2S)- (9Ci)
CAS No.	204580-51-8
Molecular Formula	C7H12ClNO2
Molecular Weight	177.63 g/mol
Synonyms	(2S)-2-(Methoxymethyl)pyrrolidine-1-carbonyl chloride; L-Proline, 2-(methoxymethyl)-, 1-chlorocarbonyl- (8CI); (S)-2-(Methoxymethyl)-1-pyrrolidinecarbonyl chloride; (S)-N-Carboxy-2-(methoxymethyl)pyrrolidine chloride; 1-Pyrrolidinecarbonyl chloride, 2-(methoxymethyl)-, (S)-; (S)-2-(Methoxymethyl)pyrrolidine-1-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 1-Pyrrolidinecarbonyl Chloride, 2-(Methoxymethyl)-, (2S)- (9Ci) is manufactured under strict quality control protocols to ensure it meets the high-purity standards required for research and pharmaceutical development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. Our quality systems are designed to support regulatory filings, and we can provide documentation to meet relevant guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.