Description

Brostallicin CAS NO 203258-38-2 is a synthetic, minor groove-binding DNA alkylator belonging to the cyclopropylpyrroloindole (CPI) class of antitumor agents. This compound is significant for its unique mechanism of action, which involves sequence-selective DNA alkylation and is designed to overcome common drug resistance mechanisms. It is primarily of interest to pharmaceutical researchers and developers in the oncology sector for preclinical and clinical-stage anticancer drug development programs.

Application

• Anticancer Drug Development: Serves as a key active pharmaceutical ingredient (API) in research for novel chemotherapeutic agents.
• Biochemical Research: Used as a tool compound in molecular biology and pharmacology to study DNA interaction, alkylation mechanisms, and cell cycle arrest.
• Mechanism of Action Studies: Employed in research focused on overcoming multidrug resistance (MDR) in cancer cells, particularly those overexpressing P-glycoprotein.
• Preclinical Evaluation: Utilized in in vitro and in vivo models to assess efficacy, pharmacokinetics, and toxicology profiles.
• Combination Therapy Research: Investigated for potential synergistic effects when used in combination with other anticancer modalities.

Basic Information

Product Name	Brostallicin
CAS No.	203258-38-2
Molecular Formula	C₂₀H₂₀BrN₃O₄
Molecular Weight	446.30 g/mol
Synonyms	PNU-166196; Brostallicin; (1S,8S)-8-[(2-Bromo-5-methoxyphenyl)amino]-1,2,8,9-tetrahydro-7H-2,7,9a-triazacyclopenta[cd]phenalen-7-one; PNU 166196; ST 2965; ST-2965; Brostallicina; Brostallicinum
EINECS	Contact for details

Quality Control

Our Brostallicin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research materials. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.