Description

1H-Pyrazole-4-Carbonyl Chloride, 5-Fluoro-1,3-Dimethyl- (9Ci) is a high-purity, functionalized heterocyclic building block essential for advanced organic synthesis. This compound serves as a critical acylating agent, enabling the efficient introduction of the 5-fluoro-1,3-dimethylpyrazole-4-carbonyl moiety into target molecules. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that incorporate the fluorinated pyrazole scaffold.
• Chemical Biology & Proteomics: Acts as a reactive handle for labeling studies, activity-based protein profiling (ABPP), and the development of molecular probes.
• Material Science Research: Employed in the creation of novel polymers, ligands for catalysis, and specialty chemicals with tailored properties.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis projects and scale-up activities.

Basic Information

Product Name	1H-Pyrazole-4-Carbonyl Chloride, 5-Fluoro-1,3-Dimethyl- (9Ci)
CAS No.	202476-26-4
Molecular Formula	C6H6ClFN2O
Molecular Weight	176.58 g/mol
Synonyms	5-Fluoro-1,3-dimethyl-1H-pyrazole-4-carbonyl chloride; 5-Fluoro-1,3-dimethylpyrazole-4-carbonyl chloride; 1,3-Dimethyl-5-fluoropyrazole-4-carbonyl chloride; 4-Carbonyl chloride-5-fluoro-1,3-dimethylpyrazole; 202476-26-4; 5-Fluoro-1,3-dimethyl-1H-pyrazole-4-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 1H-Pyrazole-4-Carbonyl Chloride, 5-Fluoro-1,3-Dimethyl- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically exceeding 97% (by HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support cGMP compliance for advanced applications and can provide material for regulatory filings upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.