Description

2-Thiophenecarbonyl Chloride, 3-(Difluoromethoxy)- (9Ci) is a specialized heterocyclic building block and key acyl chloride intermediate. This compound is valued for its unique molecular architecture, which combines a thiophene core with a difluoromethoxy substituent, enabling precise chemical modifications in advanced synthesis. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex active molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance metabolic stability and bioavailability.
• Material Science Research: Serves as a precursor for functionalized monomers or ligands in the development of advanced polymers, liquid crystals, or conductive materials.
• Chemical Biology & Proteomics: Can be utilized as a reactive handle for bioconjugation or as a scaffold in the design of enzyme inhibitors and molecular probes.
• Custom Synthesis & Contract Manufacturing: A critical raw material for fine chemical manufacturers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	2-Thiophenecarbonyl Chloride, 3-(Difluoromethoxy)- (9Ci)
CAS No.	202400-93-9
Molecular Formula	C7H3ClF2O2S
Molecular Weight	224.61 g/mol
Synonyms	3-(Difluoromethoxy)thiophene-2-carbonyl chloride; 3-(Difluoromethoxy)-2-thiophenecarbonyl chloride; 2-Thiophenecarbonyl chloride, 3-(difluoromethoxy)-; 3-(Difluoromethoxy)thiophene-2-carboxylic acid chloride; 3-Difluoromethoxythiophene-2-carbonyl chloride; 2-Carbonyl chloride-3-difluoromethoxythiophene
EINECS	Contact for details

Quality Control

Every batch of 2-Thiophenecarbonyl Chloride, 3-(Difluoromethoxy)- (9Ci) is produced and tested under a strict quality management system. We ensure high purity and consistency suitable for demanding research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent derivative, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, open flames, and incompatible materials such as bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.