Description

2'-Deoxy-N2-Isopropylguanosine is a modified nucleoside analog of guanosine, featuring an isopropyl group at the N2 position of the guanine base. This specific structural modification is of significant interest in advanced pharmaceutical research and development, particularly for its potential role in probing enzyme mechanisms and designing novel therapeutic agents. It serves as a critical building block and research chemical for scientists in medicinal chemistry, biochemistry, and oligonucleotide synthesis.

Application

• Medicinal Chemistry Research: Key intermediate in the synthesis of novel nucleoside-based pharmaceuticals and prodrugs.
• Biochemical Probes: Used to study the substrate specificity and inhibition of enzymes like kinases, polymerases, and methyltransferases.
• Oligonucleotide Synthesis: Serves as a modified phosphoramidite or solid-support precursor for incorporating specific functionalities into DNA/RNA strands.
• Antiviral/Anticancer Agent Development: Investigated for its potential biological activity and as a scaffold for creating targeted therapies.
• Academic & Institutional Research: Fundamental tool for studying nucleic acid chemistry, metabolism, and structure-activity relationships (SAR).
• Process Development & Scale-up: Used in optimizing synthetic routes for the production of higher-value active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2'-Deoxy-N2-Isopropylguanosine
CAS No.	201528-73-6
Molecular Formula	C13H19N5O4
Molecular Weight	309.32 g/mol
Synonyms	2'-Deoxy-N2-isopropylguanosine; N2-Isopropyl-2'-deoxyguanosine; 2'-Deoxy-N2-(1-methylethyl)guanosine; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-(propan-2-ylamino)-1H-purin-6-one; Isopropyl-dG; N2-iPr-dG; dG(iPr) nucleoside; Modified deoxyguanosine analog
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-N2-Isopropylguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment to ensure traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.