Description

(-)-Talarozole is a potent and selective retinoic acid metabolism-blocking agent (RAMBA) of significant interest in pharmaceutical research and development. Its core value lies in its ability to modulate retinoic acid signaling, a critical pathway involved in cellular differentiation and proliferation. This compound is primarily needed by research institutions and pharmaceutical companies engaged in developing novel therapeutics for dermatological conditions, oncology, and other diseases mediated by retinoid pathways. High-purity (-)-Talarozole CAS NO 201410-67-5 is essential for ensuring reliable and reproducible experimental and preclinical outcomes.

Application

• Pharmaceutical R&D Intermediate: Serves as a key chiral building block or active pharmaceutical ingredient (API) in the synthesis of investigational drugs.
• Dermatology Research: Used in studies targeting psoriasis, acne, and other keratinization disorders by inhibiting CYP26 enzymes to increase endogenous retinoic acid levels.
• Oncology Research: Investigated for its potential role in cancer therapy, particularly for cancers where retinoic acid metabolism is dysregulated.
• Biochemical Tool Compound: Employed in vitro and in vivo to study the physiological and pathological roles of the retinoic acid metabolic pathway.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	(-)-Talarozole
CAS No.	201410-67-5
Molecular Formula	C21H21N3O2
Molecular Weight	347.41 g/mol
Synonyms	R115866; Talarozole; (R)-N-[4-[2-Ethyl-1-(1H-1,2,4-triazol-1-yl)butyl]phenyl]-2-benzofurancarboxamide; R-115866; (-)-R115866; (R)-Talarozole; RAMBA R115866
EINECS	Contact for details

Quality Control

Our (-)-Talarozole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.