Description

1-[2,5-Anhydro-4-C-(Hydroxymethyl)-α-L-Lyxofuranosyl]-2,4(1H,3H)-Pyrimidinedione is a specialized nucleoside analogue with significant potential in advanced pharmaceutical research and development. This compound is valued for its role as a key synthetic intermediate or building block in the creation of novel antiviral and anticancer therapeutics. It is primarily sought by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of modified nucleosides. The precise molecular architecture of this pyrimidinedione derivative makes it a critical component for probing biological pathways and developing targeted drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel antiviral and anticancer nucleoside analogues.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand nucleoside metabolism and related pathways.
• Antiviral Drug Development: Investigated for incorporation into prodrugs targeting viruses such as hepatitis and herpes viruses.
• Oncology Research: Explored for the development of chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Molecular Probes: Utilized in the design of labeled compounds for diagnostic assays and imaging studies.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-[2,5-Anhydro-4-C-(Hydroxymethyl)-α-L-Lyxofuranosyl]-2,4(1H,3H)-Pyrimidinedione
CAS No.	200435-92-3
Molecular Formula	C10H12N2O7
Molecular Weight	272.21 g/mol
Synonyms	2,4(1H,3H)-Pyrimidinedione, 1-[2,5-anhydro-4-C-(hydroxymethyl)-α-L-lyxofuranosyl]-; 1-(2,5-Anhydro-4-C-hydroxymethyl-α-L-lyxofuranosyl)uracil; Anhydrohydroxymethyllyxofuranosyluracil; Lyxofuranosyl uracil derivative; Modified L-nucleoside; Uracil lyxofuranoside analogue; CAS 200435-92-3
EINECS	Contact for details

Quality Control

Our production of 1-[2,5-Anhydro-4-C-(Hydroxymethyl)-α-L-Lyxofuranosyl]-2,4(1H,3H)-Pyrimidinedione adheres to stringent quality protocols suitable for research and pharmaceutical intermediate applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistent identity and potency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We support compliance with cGMP guidelines where required for advanced R&D and pre-clinical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.