Description

Benzoyl Chloride, 4-(Chloromethyl)-3-Fluoro- (9Ci) CAS NO 200418-17-3 is a highly reactive and versatile fluorinated benzoyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the simultaneous presence of the reactive benzoyl chloride group and the chloromethyl and fluorine substituents, enabling precise molecular modifications for creating complex, high-value compounds. This intermediate is essential for research and production in the pharmaceutical and agrochemical sectors, where it is used to develop novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated drug candidates, particularly for central nervous system (CNS) agents, anti-cancer compounds, and anti-inflammatory medications.
• Agrochemical Synthesis: Used to construct advanced fluorinated pesticides and herbicides, where the fluorine atom improves metabolic stability, bioavailability, and activity.
• Liquid Crystal & OLED Material Production: Serves as a building block for fluorinated aromatic cores in electronic and display materials, enhancing thermal stability and optical properties.
• Polymer Chemistry: Acts as a monomer or modifier for introducing benzoyl and fluorine functionalities into specialty polymers, affecting their solubility and chemical resistance.
• Cross-coupling Reactions: The chloromethyl group facilitates further functionalization via Suzuki, Heck, or other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Peptide & Protein Modification: The benzoyl chloride moiety can be used for acylation reactions to label or modify biomolecules for research and diagnostic applications.

Basic Information

Product Name	Benzoyl Chloride, 4-(Chloromethyl)-3-Fluoro- (9Ci)
CAS No.	200418-17-3
Molecular Formula	C8H5Cl2FO
Molecular Weight	207.03 g/mol
Synonyms	4-(Chloromethyl)-3-fluorobenzoyl chloride; 3-Fluoro-4-(chloromethyl)benzoyl chloride; 2-Fluoro-4-(chlorocarbonyl)benzyl chloride; Benzoyl chloride, 4-(chloromethyl)-3-fluoro-; 4-Chloromethyl-3-fluorobenzoic acid chloride; α,4-Dichloro-3-fluorotoluene; (3-Fluoro-4-chloromethylphenyl)methanoyl chloride
EINECS	Contact for details

Quality Control

Our production of Benzoyl Chloride, 4-(Chloromethyl)-3-Fluoro- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to meet the exacting standards required by pharmaceutical and advanced material research. A detailed Certificate of Analysis (COA) documenting purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its properties as a strong acid/organic solvent, hygroscopic (moisture-sensitive), and highly volatile nature, it must be kept away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols. Use under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation from moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.4 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.