Description

Uridine, 4'-C-(Fluoromethyl)-3',5'-Bis-o-(Phenylmethyl)- is a chemically modified nucleoside derivative, specifically a protected fluoromethyl uridine analog. This compound is of significant interest as a key synthetic intermediate in the development of novel pharmaceuticals and advanced oligonucleotide therapeutics. It is primarily utilized by research institutions and pharmaceutical companies engaged in antiviral drug discovery, mRNA technology, and the synthesis of modified nucleic acids.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used in the research and development of modified RNA and DNA strands for therapeutic and diagnostic applications.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and nucleic acid processing.
• Probe Development: Acts as a precursor for fluorescent or radiolabeled nucleotide probes used in molecular biology and imaging.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies by introducing fluorine and benzyl protecting groups to modulate pharmacokinetic properties.
• Academic & Industrial R&D: A valuable reagent for laboratories exploring novel nucleic acid chemistries and drug delivery systems.

Basic Information

Product Name	Uridine, 4'-C-(Fluoromethyl)-3',5'-Bis-o-(Phenylmethyl)-
CAS No.	200066-88-2
Molecular Formula	C24H25FN2O6
Molecular Weight	456.47 g/mol
Synonyms	4'-C-Fluoromethyl-3',5'-di-O-benzyluridine; 3',5'-Di-O-benzyl-4'-C-fluoromethyluridine; 1-[(2R,3R,4R,5R)-3,4-Bis(benzyloxy)-5-[(fluoromethyl)oxolan-2-yl]methoxy]pyrimidine-2,4-dione; 4'-C-Fluoromethyl-3',5'-di-O-benzyl-uridine; Protected Fluoromethyl Uridine; Fluoromethyl Uridine Benzyl Ether
EINECS	Contact for details

Quality Control

Our Uridine, 4'-C-(Fluoromethyl)-3',5'-Bis-o-(Phenylmethyl)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.