Description

8-Oxoadenosine is a modified nucleoside derivative of adenosine, featuring an oxygen atom at the 8-position of the purine ring. This structural modification makes it a valuable biochemical tool and a key intermediate in the study of oxidative DNA damage and repair mechanisms. It is primarily utilized by research institutions and pharmaceutical companies engaged in nucleic acid chemistry, medicinal chemistry, and biochemical research.

Application

• Biochemical Research: Used as a standard or probe in studies of oxidative stress, DNA damage, and the activity of repair enzymes like 8-oxoguanine DNA glycosylase.
• Medicinal Chemistry: Serves as a crucial building block or intermediate in the synthesis of novel nucleoside analogs for potential therapeutic applications.
• Enzyme Substrate/Inhibitor Studies: Employed to investigate the specificity and kinetics of enzymes that process oxidized nucleosides.
• Diagnostic Development: Can be used in the development of assays and kits designed to detect and quantify oxidative damage biomarkers.
• Academic Research: A fundamental reagent for universities and labs focusing on redox biology, nucleotide metabolism, and aging-related research.
• Reference Standard: Acts as a high-purity analytical standard for HPLC, LC-MS, or NMR in quality control and method validation.

Basic Information

Product Name	8-Oxoadenosine
CAS No.	29851-57-8
Molecular Formula	C10H13N5O5
Molecular Weight	283.24 g/mol
Synonyms	8-Oxo-adenosine; 8-Oxo-A; 8-Hydroxyadenosine; Adenosine, 8-hydroxy-; 8-Oxo-7,8-dihydroadenosine; 8-Oxo-dA; 8-OH-A; 8-Oxoadenine riboside
EINECS	Contact for details

Quality Control

Our 8-Oxoadenosine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity confirmation, and impurity profiles. Our quality systems are designed to meet the rigorous demands of pharmaceutical and analytical research standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.