Description

N6-Acetyl-2',3',5'-Tri-o-Acetyl-8-Hydroxyadenosine is a key protected nucleoside derivative, specifically designed for advanced synthetic chemistry and pharmaceutical research. This compound is crucial for researchers and manufacturers requiring precise control over adenosine's reactive sites during multi-step synthesis. It is primarily utilized in the development of novel nucleotide analogs, prodrugs, and as a critical intermediate for oligonucleotide synthesis and medicinal chemistry applications.

Application

• Pharmaceutical Intermediate: Serves as a vital building block in the synthesis of novel adenosine receptor agonists/antagonists and other therapeutic nucleotide analogs.
• Oligonucleotide Synthesis: Used as a protected monomer in the solid-phase synthesis of modified DNA/RNA strands for research and therapeutic applications.
• Prodrug Development: Acts as a precursor for creating prodrug forms of antiviral or anticancer nucleoside agents, enhancing bioavailability and stability.
• Medicinal Chemistry Research: Provides a versatile scaffold for structure-activity relationship (SAR) studies and the exploration of new chemical entities.
• Biochemical Tool Compound: Employed in enzymatic studies to investigate the substrate specificity of kinases, polymerases, and other nucleotide-processing enzymes.
• Labeled Compound Synthesis: Used as a starting material for the preparation of isotopically labeled (e.g., 13C, 15N) adenosine derivatives for metabolic tracing and NMR studies.

Basic Information

Product Name	N6-Acetyl-2',3',5'-Tri-o-Acetyl-8-Hydroxyadenosine
CAS No.	29851-55-6
Molecular Formula	C20H23N5O10
Molecular Weight	493.42 g/mol
Synonyms	8-Hydroxy-N6-acetyl-2',3',5'-tri-O-acetyladenosine; 8-Hydroxyadenosine, N6-acetyl-2',3',5'-triacetate; 2',3',5'-Tri-O-acetyl-N6-acetyl-8-hydroxyadenosine; N6-Acetyl-8-hydroxyadenosine 2',3',5'-triacetate; 8-Hydroxy-N6-acetyladenosine triacetate; Adenosine, N6-acetyl-8-hydroxy-, 2',3',5'-triacetate
EINECS	Contact for details

Quality Control

Our N6-Acetyl-2',3',5'-Tri-o-Acetyl-8-Hydroxyadenosine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccant use and storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.