Description

8-Thioguanosine is a chemically modified nucleoside analog where the oxygen atom at the 8-position of guanosine is replaced by sulfur. This structural alteration is significant as it imparts unique biochemical properties, making it a valuable intermediate in pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the fields of nucleoside chemistry, antiviral drug discovery, and biochemical studies.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel nucleoside-based therapeutics.
• Antiviral Research: Investigated for its potential activity and as a precursor in the development of antiviral agents.
• Biochemical Probe: Used in enzymatic studies to understand the function of purine nucleoside phosphorylases and other related enzymes.
• Organic Synthesis: Serves as a specialized starting material for the preparation of more complex thioguanine derivatives.
• Life Science Research: Employed in academic and industrial R&D for studying RNA metabolism and modification.

Basic Information

Product Name	8-Thioguanosine
CAS No.	29836-03-1
Molecular Formula	C10H13N5O4S
Molecular Weight	299.31 g/mol
Synonyms	8-Thioguanosine; 8-Mercaptoguanosine; 8-SG; 8-Thio-Guanosine; Guanosine, 8-thio-; 9-β-D-Ribofuranosyl-8-thioguanine; 8-Thio-guanosine
EINECS	Contact for details

Quality Control

Our 8-Thioguanosine is produced under controlled conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.