Description

Adenosine,8-(Methylthio)- (7Ci,8Ci,9Ci) CAS NO 29836-01-9 is a chemically modified nucleoside derivative, specifically an 8-thioether-substituted adenosine analog. This structural modification makes it a valuable intermediate and reference standard in advanced pharmaceutical research and development. It is primarily utilized by research scientists and process chemists in the life sciences sector for investigating nucleoside metabolism, enzyme inhibition, and as a precursor for novel therapeutic agents. Its defined structure is critical for studies in medicinal chemistry and biochemical pathway analysis.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel nucleoside-based drugs and prodrugs.
• Biochemical Research: Used as a reference standard and substrate analog in enzymatic studies, particularly those involving adenosine deaminase or kinase pathways.
• Medicinal Chemistry: Acts as a core scaffold for structure-activity relationship (SAR) studies to develop new therapeutic candidates targeting purinergic receptors.
• Process Development: Employed in the scale-up and optimization of synthetic routes for complex nucleoside analogs under GMP or non-GMP conditions.
• Academic Research: Utilized in university and institutional labs for fundamental research in chemical biology and nucleotide chemistry.
• Analytical Standard: Provides a high-purity compound for method development and validation in HPLC, LC-MS, and other analytical techniques.

Basic Information

Product Name	Adenosine,8-(Methylthio)- (7Ci,8Ci,9Ci)
CAS No.	29836-01-9
Molecular Formula	C11H15N5O4S
Molecular Weight	313.33 g/mol
Synonyms	8-(Methylthio)adenosine; 8-Methylmercaptoadenosine; 8-MTA; 8-(Methylsulfanyl)adenosine; 9-β-D-Ribofuranosyl-8-(methylthio)adenine; Adenosine, 8-(methylthio)-; 8-Methylthioadenosine; NSC 154020
EINECS	Contact for details

Quality Control

Our Adenosine,8-(Methylthio)- is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS). Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific customer or regulatory requirements for research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.