Description

Dihydronovobiocin is a semi-synthetic derivative of the natural antibiotic novobiocin, specifically the dihydro form. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a specific inhibitor of the DNA gyrase B subunit and the heat shock protein 90 (Hsp90). It serves as a critical research tool for scientists and developers in the life sciences sector, particularly those investigating bacterial DNA replication mechanisms, cancer therapeutics, and protein folding pathways.

Application

• Biochemical Research: Used as a specific inhibitor to study the function of DNA gyrase in bacterial systems.
• Antibiotic Mechanism Studies: A key reference compound for investigating the structure-activity relationships of coumarin-class antibiotics.
• Oncology Research: Employed in preclinical studies targeting Hsp90 for potential anti-cancer drug development.
• Microbiology: Serves as a selective agent in microbial genetics and resistance studies.
• Pharmaceutical Intermediates: Can be utilized in the synthesis and development of novel therapeutic agents.
• Academic & Institutional Labs: Fundamental tool for teaching and advanced research in enzymology and molecular biology.

Basic Information

Product Name	Dihydronovobiocin
CAS No.	29826-16-2
Molecular Formula	C₃₁H₃₆N₂O₁₁
Molecular Weight	600.63 g/mol
Synonyms	Dihydrostreptonovobiocin; Albamycin; Cathomycin; Novobiocin Dihydro Derivative; 5',5''-Dihydronovobiocin; 7-[[4-O-(Aminocarbonyl)-2,6-dideoxy-β-D-glucopyranosyl]oxy]-4-hydroxy-3-(4-hydroxy-3-methyl-2-butenyl)-8-methyl-2H-1-benzopyran-2-one; Antibiotic PA 93 Dihydro Derivative
EINECS	Contact for details

Quality Control

Our Dihydronovobiocin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A Certificate of Analysis (COA) detailing specific results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.