Description

n-(p-Tosyl)-L-Phenylalaninyl Chloride is a protected amino acid derivative, specifically a tosylated phenylalanine acid chloride. This compound is a critical chiral building block in organic synthesis, valued for its high reactivity as an acylating agent. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for the synthesis of peptides, peptidomimetics, and other bioactive molecules where the stereochemical integrity of the L-phenylalanine moiety must be preserved.

Application

• Peptide Synthesis: A key intermediate for the controlled introduction of the L-phenylalanine residue under mild conditions.
• Pharmaceutical Intermediates: Used in the research and production of active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Acts as a reagent for modifying proteins, antibodies, or other biomolecules.
• Protease Inhibitor Development: Serves as a scaffold or precursor in the design of enzyme inhibitors.
• Chemical Biology Probes: Employed in the synthesis of labeled or tagged compounds for biological studies.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or building block in stereoselective chemical transformations.

Basic Information

Product Name	n-(p-Tosyl)-L-Phenylalaninyl Chloride
CAS No.	29739-88-6
Molecular Formula	C₁₆H₁₆ClNO₃S
Molecular Weight	337.82 g/mol
Synonyms	N-[(4-Methylphenyl)sulfonyl]-L-phenylalanyl chloride; N-Tosyl-L-phenylalanine acid chloride; N-(p-Toluenesulfonyl)-L-phenylalanine chloride; L-Phenylalanine, N-[(4-methylphenyl)sulfonyl]-, acid chloride; Tosyl-L-phenylalanine chloride; N-Tosyl-L-Phe-Cl; TOS-PHE-CL; (2S)-2-[(4-Methylphenyl)sulfonylamino]-3-phenylpropanoyl chloride
EINECS	Contact for details

Quality Control

Our n-(p-Tosyl)-L-Phenylalaninyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.