Description

12α-Hydroxy-3-Methoxyestra-1,3,5(10)-Trien-17-One is a high-purity steroid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate and reference standard for the production and analysis of complex steroidal molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents and analytical methods. The compound's defined structure and purity are essential for ensuring reproducible results in both synthetic pathways and quality control protocols.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex steroidal drugs and active pharmaceutical ingredients (APIs).
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development, validation, and quality control of steroidal products.
• Biochemical Research: Employed in academic and industrial research to study steroid metabolism, receptor interactions, and biological pathways.
• Process Development: Serves as a starting material or intermediate in scaling up and optimizing manufacturing processes for steroidal compounds.
• Metabolite Studies: Utilized in the identification and quantification of steroidal metabolites in pharmacokinetic and bioanalytical research.

Basic Information

Item	Details
Product Name	12α-Hydroxy-3-Methoxyestra-1,3,5(10)-Trien-17-One
CAS No.	29461-94-7
Molecular Formula	C19H26O3
Molecular Weight	302.41 g/mol
Synonyms	12α-Hydroxy-3-methoxyestra-1,3,5(10)-trien-17-one; 12α-Hydroxy-3-methoxy-1,3,5(10)-estratrien-17-one; 3-Methoxy-12α-hydroxyestra-1,3,5(10)-trien-17-one; 12α-Hydroxy-3-methoxyestra-1,3,5(10),16-tetraen-17-one (related name); Estra-1,3,5(10)-triene-3,12α-diol-17-one 3-methyl ether
EINECS	Contact for details

Quality Control

Our 12α-Hydroxy-3-Methoxyestra-1,3,5(10)-Trien-17-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all test results against established specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.