Description

(R)-(-)-o-Formylmandeloyl Chloride is a high-purity chiral building block and key intermediate in organic synthesis. This compound is of significant value for the preparation of enantiomerically pure pharmaceuticals and fine chemicals, enabling the construction of complex molecular architectures. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors for developing active ingredients and specialty compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of enantiopure active pharmaceutical ingredients (APIs), particularly in cardiovascular and central nervous system (CNS) drug candidates.
• Asymmetric Synthesis: Used as a versatile reagent in stereoselective reactions, including acylations and the construction of chiral auxiliaries.
• Agrochemical Research: Serves as a building block for developing chiral herbicides, fungicides, and plant growth regulators with enhanced efficacy.
• Peptide Mimetics & Modifications: Employed in the design and synthesis of peptide analogs and conformationally constrained structures for biochemical studies.
• Ligand & Catalyst Development: Useful for preparing chiral ligands and organocatalysts used in homogeneous catalysis and enantioselective transformations.
• Fine Chemical Production: Applied in the custom synthesis of high-value specialty chemicals for electronics and advanced material applications.

Basic Information

Product Name	(R)-(-)-o-Formylmandeloyl Chloride
CAS No.	29169-64-0
Molecular Formula	C9H7ClO3
Molecular Weight	198.60 g/mol
Synonyms	(R)-2-Formyloxy-2-phenylacetyl chloride; (R)-(-)-2-Formyloxy-2-phenylethanoyl chloride; (R)-α-Formyloxybenzeneacetyl chloride; (R)-O-Formylmandelic acid chloride; (R)-Mandelic acid formate chloride; (R)-OFM-Cl; (R)-(-)-OFM-Cl; (2R)-2-(Formyloxy)-2-phenylacetyl chloride
EINECS	Contact for details

Quality Control

Our (R)-(-)-o-Formylmandeloyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for research and production use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.