Description

2-Thiouridine 5'-Phosphate is a modified nucleoside monophosphate where the oxygen atom at the 2-position of the uracil ring is replaced by sulfur. This biochemical is a critical building block and research tool in the study of RNA structure, function, and modification, particularly relevant to tRNA stability and function. It is essential for researchers and manufacturers in the fields of nucleic acid chemistry, biochemistry, and pharmaceutical development, where precise molecular probes and synthetic intermediates are required.

Application

• Biochemical Research: Used as a substrate or intermediate in enzymatic studies and metabolic pathway investigations related to RNA modification.
• Nucleic Acid Synthesis: Serves as a specialized phosphoramidite or raw material for the solid-phase synthesis of modified oligonucleotides.
• Structural Biology: Employed to study the effects of thiolation on RNA folding, stability, and tertiary structure, particularly in tRNA molecules.
• Pharmaceutical Development: Investigated as a potential component in the design of novel therapeutic agents, including antisense oligonucleotides and RNA-based vaccines.
• Diagnostic Reagents: Can be utilized in the development of probes and assays for detecting specific RNA modifications or related enzymes.
• Enzyme Mechanism Studies: Acts as a probe to understand the specificity and catalytic mechanism of kinases, phosphatases, and RNA-modifying enzymes.

Basic Information

Product Name	2-Thiouridine 5'-Phosphate
CAS No.	29123-25-9
Molecular Formula	C9H13N2O8PS
Molecular Weight	340.25 g/mol
Synonyms	2-Thiouridine 5'-Monophosphate; 2-Thio-UMP; 2-S-UMP; 5'-Uridylic acid, 2-thio-; 2-Thiouridylic acid; s2UMP; 2-Thio-5'-uridylic acid; 2-Thiouridine phosphate
EINECS	Contact for details

Quality Control

Our 2-Thiouridine 5'-Phosphate is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. We provide Certificates of Analysis (COA) with each shipment, detailing all relevant specifications to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.