Description

3',5'-Dideoxythymidine is a chemically modified nucleoside analog, a key intermediate in the synthesis of specialized oligonucleotides and antiviral compounds. Its value lies in its role as a building block for creating DNA/RNA analogs with altered sugar-phosphate backbones, which are crucial for research in molecular biology, virology, and therapeutic development. This high-purity intermediate is essential for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on nucleoside chemistry, antisense technology, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used in the preparation of dideoxy-terminated DNA fragments for sequencing and molecular biology research.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies involving DNA polymerases and reverse transcriptases.
• Antisense & Aptamer Development: A key component in creating nuclease-resistant oligonucleotides for therapeutic and diagnostic applications.
• Probe Synthesis: Utilized in the manufacture of labeled nucleotides for diagnostic assays and hybridization probes.
• Reference Standard: Acts as a high-purity analytical standard for quality control in pharmaceutical manufacturing and research.

Basic Information

Product Name	3',5'-Dideoxythymidine
CAS No.	29108-89-2
Molecular Formula	C10H14N2O4
Molecular Weight	226.23 g/mol
Synonyms	2'-Deoxythymidine 3',5'-dideoxy derivative; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione; 3',5'-Dideoxy Thymidine; ddThd; Dideoxythymidine (ambiguous); 5-Methyl-2'-deoxyuridine 3',5'-dideoxy (non-standard); Thymidine 3',5'-dideoxy
EINECS	Contact for details

Quality Control

Our 3',5'-Dideoxythymidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including research-grade and GMP-grade standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.