Description

Cyclobuta-Dithymidine is a specialized nucleoside derivative of significant interest in advanced pharmaceutical research and development. Its unique cyclobutane-fused structure makes it a valuable building block for the synthesis of novel antiviral and anticancer compounds, particularly in the field of modified oligonucleotides. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality raw materials for complex synthetic pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside analog drugs targeting viral infections and oncology.
• Antiviral Drug Development: Used in research for creating next-generation therapeutics against DNA viruses.
• Oligonucleotide Synthesis: Serves as a modified building block for antisense oligonucleotides and other therapeutic nucleic acids.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies related to DNA metabolism and repair.
• Fine Chemical Synthesis: A versatile chiral synthon for constructing complex molecular architectures in medicinal chemistry.
• Reference Standard: Used as an analytical standard in quality control laboratories for drug substance characterization.

Basic Information

Product Name	Cyclobuta-Dithymidine
CAS No.	28806-14-6
Molecular Formula	C20H24N4O9
Molecular Weight	464.43 g/mol
Synonyms	Cyclobutadithymidine; 1,3-Bis(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)cyclobutane; Cyclobutane-1,3-diyl bis(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-1-carboxylate); 1,3-Cyclobutylene dithymidine; Dithymidine Cyclobutane Dimer; Cyclobutadithymine Dimer; (1,3-Cyclobutanediyl)bis(thymine)
EINECS	Contact for details

Quality Control

Our Cyclobuta-Dithymidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of the pharmaceutical industry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.