Description

Pyrrolo(1,2,3-Ef)(1,5)Benzodiazepine, 1,2,4,5,6,7-Hexahydro-, Dihydrochloride is a high-purity benzodiazepine derivative, a critical advanced intermediate in modern pharmaceutical synthesis. This compound is valued for its defined chemical structure, which serves as a key building block for developing novel active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of specialized therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs) for central nervous system (CNS) research.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and the development of new therapeutic candidates.
• Process Chemistry Development: Used in optimizing scalable synthetic routes for the production of complex drug molecules in pilot and commercial-scale manufacturing.
• Reference Standard: Employed as a high-purity analytical standard for quality control, method development, and regulatory submissions in pharmaceutical analysis.
• Biochemical Research: Investigated for its potential interactions with various biological receptors and enzymes in preclinical studies.

Basic Information

Product Name	Pyrrolo(1,2,3-Ef)(1,5)Benzodiazepine, 1,2,4,5,6,7-Hexahydro-, Dihydrochloride
CAS No.	28740-82-1
Molecular Formula	C12H16N2 • 2HCl
Molecular Weight	261.19 g/mol (Free base: 188.27 g/mol)
Synonyms	1,2,4,5,6,7-Hexahydropyrrolo[1,2,3-ef][1,5]benzodiazepine Dihydrochloride; Pyrrolobenzodiazepine Dihydrochloride; PBD Dihydrochloride; 1,5-Benzodiazepine, hexahydropyrrolo derivative dihydrochloride; NSC 338720 (dihydrochloride); Hexahydro-1H-pyrrolo[1,2,3-ef][1,5]benzodiazepine dihydrochloride
EINECS	Contact for details

Quality Control

Our production of this pharmaceutical intermediate adheres to strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your internal specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.