Description

2-Thiothymidine is a modified nucleoside analog where the oxygen atom in the thymidine sugar moiety is replaced by sulfur. This structural modification is critical for its role as a key intermediate and building block in the synthesis of oligonucleotides and other bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in nucleic acid chemistry, antiviral drug development, and molecular biology research.

Application

• Oligonucleotide Synthesis: A vital phosphoramidite precursor for incorporating thionucleoside modifications into DNA/RNA strands.
• Antiviral Research: Serves as a core scaffold in the development of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral agents.
• Biochemical Probes: Used to create labeled nucleotides and probes for studying nucleic acid structure, function, and protein interactions.
• Medicinal Chemistry: An essential intermediate for synthesizing novel therapeutic candidates targeting viral and genetic diseases.
• Academic Research: Employed in universities and research labs for fundamental studies on nucleic acid analogs and their biochemical properties.

Basic Information

Product Name	2-Thiothymidine
CAS No.	28585-51-5
Molecular Formula	C10H14N2O4S
Molecular Weight	258.30 g/mol
Synonyms	2-Thio-2'-deoxythymidine; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-2-thiothymine; 2'-Deoxy-2-thiothymidine; 2-Thiothymine deoxyriboside; dT(S); 2-Thio-dT; 2-Thiothymidine (2'-deoxy)
EINECS	Contact for details

Quality Control

Our 2-Thiothymidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.