Description

2,4-Dithiouridine 2'',3'',5''-Triacetate is a key protected nucleoside derivative, essential for advanced oligonucleotide synthesis and pharmaceutical research. Its value lies in providing a reactive scaffold for the controlled introduction of sulfur-modified bases, enabling the study of RNA structure, function, and stability. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostic probes, and biochemical tools.

Application

• Oligonucleotide Synthesis: Serves as a critical building block (phosphoramidite precursor) for the solid-phase synthesis of thio-modified RNA strands.
• Pharmaceutical Research: Used in the development of antisense oligonucleotides, siRNA, and other RNA-based therapeutic agents where enhanced nuclease resistance or altered binding affinity is desired.
• Biochemical Studies: A vital tool for investigating RNA structure-function relationships, folding, and protein-RNA interactions through site-specific sulfur incorporation.
• Diagnostic Probe Development: Employed in creating labeled probes for detection and analysis, leveraging the unique properties of the thio-modified nucleobase.
• Medicinal Chemistry: Acts as an intermediate in the synthesis of novel nucleoside analogs with potential antiviral or anticancer activity.

Basic Information

Product Name	2,4-Dithiouridine 2'',3'',5''-Triacetate
CAS No.	28542-32-7
Molecular Formula	C15H18N2O8S2
Molecular Weight	418.44 g/mol
Synonyms	1-[(2R,3R,4R,5R)-3,4-Diacetoxy-5-(acetoxymethyl)oxolan-2-yl]-2,4-dithiopyrimidine; 2,4-Dithio-2',3',5'-tri-O-acetyluridine; 2,4-Dithiouridine triacetate; 2-Thio-4-thiouridine 2',3',5'-triacetate; Uridine, 2,4-dithio-, 2',3',5'-triacetate
EINECS	Contact for details

Quality Control

Our 2,4-Dithiouridine 2'',3'',5''-Triacetate is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.