Description

2',3',5'-Tri-o-Acetyl-2-Thiouridine is a key protected nucleoside derivative used as a critical building block in oligonucleotide synthesis and pharmaceutical research. This compound is essential for the development of modified RNA and DNA sequences, enabling advanced studies in molecular biology, antisense therapy, and drug discovery. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers specializing in nucleotide chemistry and therapeutic nucleic acid production.

Application

• Oligonucleotide Synthesis: Serves as a vital phosphoramidite precursor for the solid-phase synthesis of thio-modified RNA strands.
• Antisense & siRNA Research: Used in the development of therapeutic oligonucleotides with enhanced nuclease resistance and binding affinity.
• Pharmaceutical Intermediates: Acts as a protected intermediate in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Biochemical Probes: Employed in the creation of labeled probes and primers for diagnostic assays and genomic studies.
• Medicinal Chemistry: Provides a scaffold for structure-activity relationship (SAR) studies to explore new therapeutic candidates.
• Academic Research: A fundamental reagent for universities and labs investigating RNA biology, epigenetics, and nucleic acid modifications.

Basic Information

Product Name	2',3',5'-Tri-o-Acetyl-2-Thiouridine
CAS No.	28542-31-6
Molecular Formula	C15H18N2O8S
Molecular Weight	386.38 g/mol
Synonyms	2-Thiouridine, 2',3',5'-triacetate; 2-Thio-2',3',5'-tri-O-acetyluridine; 1-(2,3,5-Tri-O-acetyl-β-D-ribofuranosyl)-2-thiouracil; 2',3',5'-Tri-O-acetyl-2-thiouridine; 2-Thiouridine triacetate; 2-S-2',3',5'-Tri-O-acetyluridine; TRIACETYL-2-THIOURIDINE
EINECS	Contact for details

Quality Control

Our 2',3',5'-Tri-o-Acetyl-2-Thiouridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for sensitive research and synthesis applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.