Description

12β-[[(Z)-3,4-Dimethyl-1-Oxo-2-Pentenyl]Oxy]-3β,8,14β-Trihydroxypregn-5-En-20-One is a high-purity, semi-synthetic pregnane derivative with a complex, functionalized structure. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) and a valuable scaffold for medicinal chemistry research. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel steroid-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and drug discovery programs targeting hormone receptors.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Research: Investigated for its potential biological activity and interactions with enzymatic pathways in preclinical studies.
• Fine Chemical Synthesis: Utilized in multi-step organic syntheses to create more complex, functionally diverse steroid analogs.

Basic Information

Product Name	12β-[[(Z)-3,4-Dimethyl-1-Oxo-2-Pentenyl]Oxy]-3β,8,14β-Trihydroxypregn-5-En-20-One
CAS No.	28421-74-1
Molecular Formula	C₂₈H₄₂O₆
Molecular Weight	474.64 g/mol
Synonyms	12β-[(Z)-3,4-Dimethyl-1-oxo-2-penten-1-yl]oxy]-3β,8,14β-trihydroxypregn-5-en-20-one; 3β,8,14β-Trihydroxy-12β-[[(2Z)-3,4-dimethyl-1-oxo-2-penten-1-yl]oxy]pregn-5-en-20-one; (3β,12β)-3,8,14-Trihydroxy-12-[[(2Z)-3,4-dimethyl-1-oxopent-2-en-1-yl]oxy]pregn-5-en-20-one; Pregn-5-en-20-one, 12-[[(2Z)-3,4-dimethyl-1-oxo-2-penten-1-yl]oxy]-3,8,14-trihydroxy-, (3β,12β)-; 12β-O-(3,4-Dimethyl-1-oxo-2-pentenyl)-3β,8,14β-trihydroxypregn-5-en-20-one
EINECS	Contact for details

Quality Control

Our 12β-[[(Z)-3,4-Dimethyl-1-Oxo-2-Pentenyl]Oxy]-3β,8,14β-Trihydroxypregn-5-En-20-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets exacting standards for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.