Description

1-Arabinofuranosyl-2-Thiocytosine is a modified nucleoside analog where the oxygen atom at the 2-position of cytosine is replaced by sulfur, and the sugar moiety is arabinofuranose. This specific molecular architecture makes it a valuable intermediate and research chemical for developing novel antiviral and anticancer therapeutics. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions engaged in nucleoside chemistry and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand the mechanisms of nucleoside-metabolizing enzymes.
• Medicinal Chemistry: Acts as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity against specific biological targets.
• Antiviral Agent Development: Investigated for its potential activity against DNA and RNA viruses due to its ability to be incorporated into nucleic acids.
• Labeled Compound Synthesis: Can be used as a precursor for synthesizing isotopically labeled (e.g., C-13, N-15) nucleosides for metabolic tracing studies.

Basic Information

Product Name	1-Arabinofuranosyl-2-Thiocytosine
CAS No.	28419-39-8
Molecular Formula	C9H13N3O4S
Molecular Weight	259.28 g/mol
Synonyms	2-Thiocytosine arabinoside; 2-Thio-ara-C; 1-β-D-Arabinofuranosyl-2-thiocytosine; 2-Thio-1-β-D-arabinofuranosylcytosine; 2-Thiocytarabine; 2-S-Cytosine arabinoside; Ara-2-thio-C; 2-Thio-cytosine-1-β-D-arabinofuranoside
EINECS	Contact for details

Quality Control

Our 1-Arabinofuranosyl-2-Thiocytosine is produced under a strict quality management system to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant standards for research chemicals, and custom synthesis to meet specific purity requirements (e.g., >98% by HPLC) is available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.