Description

3-Deazacytidine is a potent nucleoside analog and a key research-grade biochemical used to study epigenetic regulation and cellular processes. This compound is valued for its role as an inhibitor of DNA methyltransferases, making it a critical tool in oncology and molecular biology research. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics and understanding gene expression.

Application

• Epigenetics Research: Used as a DNA methyltransferase (DNMT) inhibitor to study DNA methylation patterns and gene silencing mechanisms.
• Oncology Studies: Investigated for its potential to reactivate tumor suppressor genes and its effects on cancer cell proliferation and differentiation.
• Biochemical Assays: Serves as a reference standard and active component in enzymatic and cellular assays targeting epigenetic pathways.
• Pharmaceutical Development: Employed in early-stage drug discovery for diseases where epigenetic dysregulation is a key factor.
• Cell Biology: Used to induce cellular differentiation and study the impact of hypomethylation on various cell lines.

Basic Information

Product Name	3-Deazacytidine
CAS No.	28307-19-9
Molecular Formula	C8H12N4O4
Molecular Weight	228.21 g/mol
Synonyms	5-Aza-2'-deoxycytidine (Dacogen analog); 3-Deaza-2'-deoxycytidine; 4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one; 5-Aza-dCyd; NSC 127716; DZCdR; 3-DeazadC
EINECS	Contact for details

Quality Control

Our 3-Deazacytidine is produced under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.