Description

1H-Azepine-1-Carbonyl Chloride, 7-Chloro-2,3,4,5-Tetrahydro-4-Methyl- (8Ci) is a specialized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a reactive acyl chloride derivative, enabling the efficient introduction of the 1H-azepine scaffold into target molecules under controlled conditions. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel therapeutic agents, particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Research: Used in the development of new pesticides and herbicides with unique modes of action.
• Chemical Biology Probes: Serves as a precursor for creating labeled compounds or affinity probes to study biological pathways.
• Material Science: Potential monomer or cross-linking agent in the development of specialty polymers with specific thermal or mechanical properties.
• Academic & Contract Research: Essential reagent for methodological studies and the exploration of new synthetic routes in heterocyclic chemistry.
• Scale-up & Process Chemistry: Investigated for use in optimizing kilogram-scale synthetic routes for candidate drugs.

Basic Information

Product Name	1H-Azepine-1-Carbonyl Chloride, 7-Chloro-2,3,4,5-Tetrahydro-4-Methyl- (8Ci)
CAS No.	28288-10-0
Molecular Formula	C8H11Cl2NO
Molecular Weight	208.09 g/mol
Synonyms	7-Chloro-4-methyl-2,3,4,5-tetrahydro-1H-azepine-1-carbonyl chloride; 4-Methyl-7-chloro-2,3,4,5-tetrahydro-1H-azepine-1-carbonyl chloride; 1-Carbonylchloride-7-chloro-4-methyl-2,3,4,5-tetrahydro-1H-azepine; 7-Chloro-4-methyl-1,2,3,5-tetrahydro-4H-azepine-1-carbonyl chloride; Tetrahydroazepine carbonyl chloride derivative
EINECS	Contact for details

Quality Control

Our production of 1H-Azepine-1-Carbonyl Chloride, 7-Chloro-2,3,4,5-Tetrahydro-4-Methyl- (8Ci) adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for your critical research and development work. Each lot undergoes comprehensive analytical characterization. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.