Description

Benzoyl Chloride, 4-Hydroxy- (9Ci) CAS NO 28141-24-4 is a key aromatic acid chloride derivative, serving as a versatile and reactive building block in advanced organic synthesis. Its bifunctional nature, featuring both an acid chloride and a phenolic hydroxyl group, makes it indispensable for introducing the 4-hydroxybenzoyl moiety into target molecules. This high-purity intermediate is primarily sought by R&D and production teams in the pharmaceutical, agrochemical, and specialty polymer industries for constructing complex active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting metabolic and central nervous system disorders.
• Agrochemical Synthesis: Production of herbicides, fungicides, and plant growth regulators where the 4-hydroxybenzoyl group enhances biological activity.
• Polymer Chemistry: Monomer for creating specialty polyesters, polyamides, and epoxy resins with specific thermal or UV-stabilizing properties.
• Liquid Crystal & OLED Materials: Key precursor in the manufacture of advanced electronic display components and organic light-emitting diodes.
• Dye & Pigment Manufacturing: Intermediate for producing high-performance azo dyes and pigments with improved color fastness.
• UV Absorber Production: Core building block for benzophenone-type UV filters used in plastics, coatings, and personal care formulations.
• Crosslinking Agent: Used in the formulation of high-performance adhesives, sealants, and composite materials.
• Academic & Contract Research: Valuable reagent for methodological development and novel compound library synthesis in research laboratories.

Basic Information

Product Name	Benzoyl Chloride, 4-Hydroxy- (9Ci)
CAS No.	28141-24-4
Molecular Formula	C7H5ClO2
Molecular Weight	156.57 g/mol
Synonyms	4-Hydroxybenzoyl chloride; p-Hydroxybenzoyl chloride; 4-Carboxybenzoyl chloride; 4-Hydroxybenzoic acid chloride; (4-Hydroxyphenyl)carbonyl chloride; p-Carboxyphenyl chloride; 1-(Chlorocarbonyl)-4-hydroxybenzene; Benzoic acid, 4-hydroxy-, chloride
EINECS	Contact for details

Quality Control

Our production of 4-Hydroxybenzoyl Chloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical synthesis. Each lot is subjected to comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and Karl Fischer titration for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with REACH and other global regulatory frameworks, and can tailor specifications to meet specific GMP or custom purity requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from heat, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	195 - 200 °C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.