Description

7-Methyl-2-Deoxyguanosine is a modified nucleoside derivative of deoxyguanosine, featuring a methyl group at the 7-position of the guanine base. This specific structural modification makes it a valuable biochemical tool and a critical reference standard in nucleic acid research and analytical chemistry. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic companies engaged in advanced studies of DNA damage, repair mechanisms, and epigenetic modifications. The compound's high purity and well-defined structure are essential for ensuring the accuracy and reproducibility of sensitive analytical assays.

Application

• Biochemical Research: Used as a critical standard and reagent in studies of DNA alkylation damage, repair pathways, and mutagenesis.
• Analytical Reference Standard: Serves as a high-purity calibrant and internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and HPLC methods for quantifying DNA adducts.
• Pharmaceutical Development: Employed in the research and quality control of oncology drugs that interact with or cause specific types of DNA damage.
• Diagnostic Assay Development: Utilized in the creation of diagnostic kits and methods designed to detect and quantify specific DNA lesions in biological samples.
• Toxicology Studies: Applied in research to understand the metabolic pathways and genotoxic effects of chemical carcinogens that form 7-methylguanine adducts in DNA.

Basic Information

Product Name	7-Methyl-2-Deoxyguanosine
CAS No.	28074-91-1
Molecular Formula	C11H15N5O4
Molecular Weight	281.27 g/mol
Synonyms	7-Methyl-2'-deoxyguanosine; 2'-Deoxy-7-methylguanosine; 7-Methyl-dG; N7-Methyl-2'-deoxyguanosine; 7-Methyl-deoxyguanosine; dG(7-Me); 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-methyl-6,9-dihydro-3H-purin-6-one
EINECS	Contact for details

Quality Control

Our 7-Methyl-2-Deoxyguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.