Description

3β,7α,12α-Trihydroxy-5β-Cholanic Acid Methyl Ester is a key intermediate in the synthesis of bile acids and their derivatives. This compound is critical for pharmaceutical research and development, particularly in the study of liver function and cholesterol metabolism. It is primarily utilized by manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for producing high-purity active pharmaceutical ingredients (APIs) and reference standards.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of therapeutic bile acids such as ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA).
• Biochemical Research: Used as a reference standard and precursor in metabolic pathway studies, particularly those involving cholesterol and lipid regulation.
• Fine Chemical Synthesis: Serves as a starting material for the production of specialized steroid derivatives and conjugates for diagnostic applications.
• API Development: Employed in the research and scale-up manufacturing of active pharmaceutical ingredients targeting hepatobiliary diseases.
• Metabolite Standard: Essential for analytical laboratories in developing and validating HPLC/LC-MS methods for quantifying bile acid profiles in biological samples.

Basic Information

Product Name	3β,7α,12α-Trihydroxy-5β-Cholanic Acid Methyl Ester
CAS No.	28050-54-6
Molecular Formula	C25H42O5
Molecular Weight	422.60 g/mol
Synonyms	Methyl 3α,7α,12α-trihydroxy-5β-cholan-24-oate; Methyl Cholate; Methyl 3α,7α,12α-trihydroxy-5β-cholanate; Cholic Acid Methyl Ester; 5β-Cholan-24-oic Acid, 3α,7α,12α-trihydroxy-, Methyl Ester, (3α,5β,7α,12α)-; Methyl 3α,7α,12α-trihydroxy-5β-cholanoate
EINECS	Contact for details

Quality Control

Our 3β,7α,12α-Trihydroxy-5β-Cholanic Acid Methyl Ester is manufactured under strict quality management systems. We provide material suitable for pharmaceutical research and development, with typical purity levels exceeding 98% (HPLC). A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each batch to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.