Description

4',5'-Didehydro-5'-Deoxythymidine is a modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate and a valuable scaffold for exploring novel antiviral and anticancer therapeutics. It is primarily utilized by research institutions and pharmaceutical companies engaged in nucleoside chemistry, medicinal chemistry, and the development of next-generation active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• Biochemical Research: Employed in studies investigating enzyme mechanisms, particularly those involving thymidine kinases and other nucleoside-processing enzymes.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Prodrug Development: Investigated for the design of prodrugs aimed at improving bioavailability and targeted delivery of therapeutic nucleosides.

Basic Information

Product Name	4',5'-Didehydro-5'-Deoxythymidine
CAS No.	28034-72-2
Molecular Formula	C10H12N2O4
Molecular Weight	224.21 g/mol
Synonyms	5'-Deoxy-4',5'-didehydrothymidine; 2'-Deoxythymidine, 5'-deoxy-4',5'-didehydro-; d4T Impurity; Stavudine Related Compound; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-3,4-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our 4',5'-Didehydro-5'-Deoxythymidine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.