Description

Uridine, 5'-(Hydrogen 4-Morpholinylphosphonate) is a chemically modified nucleoside analog, specifically a uridine monophosphate derivative where the phosphate group is esterified with morpholine. This compound is a critical building block and intermediate in the synthesis of nucleotide prodrugs and modified oligonucleotides. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antiviral therapeutics, mRNA technology, and novel diagnostic probes. The precise chemical structure offers a key handle for further derivatization, enabling the creation of targeted bioactive molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of nucleotide analog prodrugs for antiviral and anticancer applications.
• Oligonucleotide Synthesis: Building block for creating modified RNA/DNA strands with enhanced stability or specific binding properties for research and therapeutics.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleotide metabolism and related pathways.
• Pro-drug Development: Serves as a masked phosphate group carrier to improve the cellular uptake and bioavailability of nucleotide-based drugs.
• Diagnostic Probe Manufacturing: Incorporated into labeled nucleotides for use in diagnostic assays and sequencing technologies.

Basic Information

Product Name	Uridine, 5'-(Hydrogen 4-Morpholinylphosphonate)
CAS No.	27908-36-7
Molecular Formula	C13H20N3O9P
Molecular Weight	393.29 g/mol
Synonyms	5'-O-Phosphonomorpholino Uridine; Uridine 5'-(4-Morpholinephosphonate); 4-Morpholine-N-(uridin-5'-yl)phosphonamide; Uridine 5'-Morpholinophosphonate; 5'-Deoxy-5'-(4-morpholinylphosphinyl)uridine; Uridine 5'-(N-morpholinophosphoramidate); Morpholine uridine phosphoramidate
EINECS	Contact for details

Quality Control

Our Uridine, 5'-(Hydrogen 4-Morpholinylphosphonate) is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our production can adhere to cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccant use and storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.